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本文证明在一定条件下,斯氏按蚊对食蟹猴疟原虫的感染率为77±0.15％;恒河猴易感性强,对照组的感染率非常稳定,用10~5个以上子孢子静脉接种恒河猴可100％获得感染。在食蟹猴疟原虫—斯氏按蚊系统猴疟模型上,常用抗疟药如乙胺嘧啶、伯喹显示有病因性预防作用。伯喹剂量达到2.5mg(基质)/kg×5天,合并氯喹20mg(基质)/kg×3天显示有权治作用,氯喹20mg(基质)kg×3天则仅能显示抑制性治疗作用。
This article proves that under certain conditions, An. Sinensis infection rate of cynomolgous malaria parasite is 77 ± 0.15%; Rhesus susceptibility is strong, the infection rate in the control group is very stable, with 10 to 5 sporozoites in the vein Rhesus monkeys can be 100% infected. In the cynomolgus malaria - Anopheles stephensi system of monkey malaria models, commonly used antimalarial drugs such as pyrimethamine, primaquine showed a causal preventive effect. Quercetin dose reached 2.5mg (matrix) / kg × 5 days, combined with chloroquine 20mg (matrix) / kg × 3 days showed the right to rule role, chloroquine 20mg (matrix) kg × 3 days only show inhibitory effect.