论文部分内容阅读
目的评价降钙素原procalcitonin(PCT)在新生儿败血症中的早期诊断价值。方法选取2014—2015年收治的40例早期败血症新生儿患者作为败血症组,选择同期40例健康新生儿作为对照组,收集患者临床资料,检测其白细胞(WBC)计数、PCT和C反应蛋白(CRP)。计量资料比较采用t检验,计数资料比较采用χ~2检验,诊断灵敏度和特异性以及临界(Cut-off)值通过受试者工作曲线下面积来计算,败血症新生儿患者的WBC、PCT与CRP的相关性研究采用Spearman等级相关分析,P<0.05为差异有统计学意义。结果败血症新生儿患者的PCT和CRP高于正常对照组(均P<0.05)。PCT和CRP有明显的正相关(P=0.001,r=0.55),与WBC计数也呈正相关(P=0.2,r=0.2)。此外,PCT在诊断新生儿败血症中有较高的灵敏度、特异性、阳性预测值和阴性预测值(81%,85.6%,84.8%,81.1%),PCT的灵敏度优于CRP。结论 PCT较CRP可较好地用于诊断新生儿早期败血症。
Objective To evaluate the early diagnostic value of procalcitonin (PCT) in neonatal sepsis. Methods Forty infants with early sepsis who were treated in 2014-2015 were selected as the sepsis group. Forty healthy newborns of the same period were selected as the control group. The clinical data of the patients were collected and their white blood cell (WBC) counts, PCT and C-reactive protein (CRP) ). Measurement data were compared by t-test, count data were compared using χ ~ 2 test, diagnostic sensitivity and specificity, and cut-off values were calculated from the area under the receiver operating curve. WBC, PCT and CRP The correlation study using Spearman rank correlation analysis, P <0.05 for the difference was statistically significant. Results The PCT and CRP in neonates with sepsis were higher than those in normal control group (all P <0.05). There was a significant positive correlation between PCT and CRP (P = 0.001, r = 0.55) and positive correlation with WBC count (P = 0.2, r = 0.2). In addition, PCT had higher sensitivity, specificity, positive predictive value and negative predictive value (81%, 85.6%, 84.8%, 81.1%) in the diagnosis of neonatal sepsis. PCT was superior to CRP in sensitivity. Conclusion PCT is better than CRP in the diagnosis of early neonatal septicemia.