化学药物和辐射所诱导的DNA损伤修复通路在肿瘤治疗疗效反应上扮演了重要的角色。肿瘤细胞DNA修复能力增强是肿瘤耐受放化疗的主要机制。DNA修复过程涉及许多基因, 这些基因在遗传学及表遗传学上的改变可影响DNA修复的能力,因此通过检测这些基因的单核苷酸多态性、甲基化状态以及基因的过表达来预测疗效。现综述近年来碱基切除修复基因、核苷酸剪切修复基因及双链断裂修复基因预测非小细胞肺癌放化疗疗效的研究进展。 Chemotherapy and radiation-induced DNA damage repair pathways play an important role in the response of tumor therapy. Tumor cell DNA repair capacity is the main mechanism of tumor resistance to chemotherapy. The DNA repair process involves many genes whose genetic and epigenetic changes affect the ability of DNA repair. Therefore, by examining single nucleotide polymorphisms, methylation status, and gene overexpression of these genes Predict the efficacy. This review summarizes the recent progress in the study of the efficacy of radiotherapy and chemotherapy for non-small cell lung cancer (NSCLC) in terms of base excision repair gene, nucleotide excision repair gene and double-strand break repair gene.