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目的 研究rasp2 1和 p5 3的表达与尿路上皮肿瘤临床及预后的关系。 方法 采用免疫组织化学ABC法检测 66例尿路上皮肿瘤rasp2 1和 p5 3的表达。 结果 rasp2 1阳性表达 40例 ( 60 .6% ) ,p5 3阳性表达 3 6例 ( 5 4.5 % ) ,rasp2 1和 p5 3共同阳性表达 2 7例 ( 4 0 .9% ) ;rasp2 1和p5 3阳性表达随肿瘤病理分级和分期的上升而增强 ,与肿瘤复发及预后呈正相关性 (P <0 .0 1)。结论 rasp2 1和 p5 3的表达可作为尿路上皮肿瘤恶性程度、浸润深度、复发和预后的重要估价指标。
Objective To investigate the relationship between the expression of rasp2 1 and p5 3 and the clinical and prognosis of urothelial tumors. Methods Immunohistochemical ABC method was used to detect the expression of rasp2 1 and p5 3 in 66 cases of urothelial tumors. Results The positive expression rate of rasp2 1 was 40 cases (60.6%), the positive expression rate of p5 3 was 36.5% (5 4.5%), while the positive rates of rasp2 1 and p5 3 were 27 (40.9%). 3 positive expression increased with the pathological grade and staging of tumors, and positively correlated with tumor recurrence and prognosis (P <0.01). Conclusion The expression of rasp2 1 and p5 3 can be used as an important evaluation index of the malignant degree, depth of invasion, recurrence and prognosis of urothelial tumors.