【摘 要】
:
Osteoclastogenesis in alveolar bone induced by compression stress triggers orthodontic tooth movement.Compression stress also stimulates angiogenesis,which is essential for osteoclastogenesis.However,the effects of osteoclastogenesis induced by compressio
【机 构】
:
Department of Orthodontics,Peking University School and Hospital of Stomatology,Beijing 100081,China
论文部分内容阅读
Osteoclastogenesis in alveolar bone induced by compression stress triggers orthodontic tooth movement.Compression stress also stimulates angiogenesis,which is essential for osteoclastogenesis.However,the effects of osteoclastogenesis induced by compression on angiogenesis are poorly understood.In vivo,we found the markers ofangiogenesis increased during orthodontic bone remodeling.In vitro,osteoclast-derived exosomes increased proliferation,migration,and tube formation of human um-bilical vein endothelial cells (HUVECs),as well as expression of vascular endothelial growth factor and CD31.The promotive effects of exosomes derived from compressed osteoclasts were greater than those derived from osteoclasts without compression.Next,we analyzed changes in the microRNA transcriptome after compression stress and focused on microRNA146a-5p (miR-146a),which was significantly decreased by compression.Transfection of an inhibitor of miR-146a stimulated angiogenesis of HUVECs while miR-146a mimics repressed angiogenesis.Adiponectin (ADP) was confirmed to be a target ofmiR-146a by dual luciferase reporter assay.In HUVECs treated with exosomes,we detected increased ADP which promoted angiogenesis.Knockdown of ADP in HUVECs reduced the promotive effects of exosomes.Our results demonstrate that the decreased miR-146a observed in osteoclasts after compression promotes angiogenesis by targeting ADP,suggesting a novel method to interfere with bone remodeling induced by compression stress.
其他文献
Dear Editor,rnEquine piroplasmosis(EP)is an infectious,tick-borne dis-ease caused by the hemoprotozoan parasites Theileria equi(T.equi)and Babesia caballi(B.caballi).EP affects all wild and domestic equids,and clinical presentation is related to intravasc
中国国际形象的塑造工作对内直接影响着中国的发展,对外直接关系着中国在国际社会的影响力与号召力的水平.中国共产党自成立以来一刻也未放松过对于中国国际形象的塑造工作,在不同历史时期,中国共产党在国际形象塑造的演进历史过程中,我们积累了丰富的文化经验.进入新时代之后,中国国际形象塑造工作,在文化领域面对着全新的内容,文化软实力、国际话语权、文化自信以及意识形态,这些全新的文化内容,也为后期新时代中国国际形象塑造梳理出了全新的文化路径.
High-quality rice reference genomes have accelerated the comprehensive identification of genome-wide variations and research on functional genomics and breeding.Tian-you-hua-zhan has been a leading hybrid in China over the past decade.Here,de novo genome
Viruses utilize cellular lipids and manipulate host lipid metabolism to ensure their replication and spread.Therefore,the identification of lipids and metabolic pathways that are suitable targets for antiviral development is crucial.Using a library of com
基于公共管理视角对我国社区矫正、心理矫治现状展开分析能够发现这一领域存在一些问题:司法行政机关缺乏矫正强制权;某些部门之间存在推诿现象;矫正工作者队伍建设有待进一步强化;某些地方存在监管混乱现象.这些问题主要归因于:缺少社区矫正管理相关法律依据;心理矫治经费没有足备保障;社区矫正队伍的职业化水平、专业程度均不高;社会群体重视与参与程度低.公共管理视角下社区矫正、心理矫治的优化途径是:健全与社区矫正相关的法律法规;吸纳社会力量参与社区矫正、心理矫治;强化社区矫正队伍的建设;积极引导社会力量参与社区矫正工作.
生态地位特殊省区是提供生态产品、建设生态文明的主体区域,但这类省区内部也分布着重点开发区域,需要在主体功能区视域下审视和处理这类省区内经济开发与生态保护的协调布局问题.基于主体功能区理念,构建了一个研究生态地位特殊省区内经济开发与生态保护协调布局的分析框架,该框架包含由生态区位、环境容量、资源保障条件、现有发展基础等典型因素决定的各地之间经济重要性与生态重要性的相对大小,再根据这种相对大小明确各地国土空间开发利用的主体功能定位.并以四川省为例,基于实际收集的数据,进行了实证研究.
湾区经济是沿海经济重要形式,海洋作为高质量发展战略要地,湾区发展海洋经济直接关系到湾区高质量发展.粤港澳大湾区是国务院批准的国家战略区域,是带动南部海洋经济圈及泛珠三角区域的重大引擎.总结国际三大湾区和环杭州大湾区建设现状和经验,大湾区是城市发展的必然趋势和高阶形态,具有“江、城、湾”的地理格局,以河口地区为中心向外围扩展,城市分工明确,滨海人口密集,跨国企业总部集聚,对全国和全球经济具有绝对控制力.粤港澳大湾区未来应聚焦交通互联,激活综合型港城经济活力,海港差异化发展产业结构加强互补,强化海洋科技创新合
全力奋进打赢脱贫攻坚战是国家和政府长期放在首要的工作,在消费扶贫提出以来,各省各地区都积极响应,提出了有利于本区域的扶贫手段和方案.文章在分析研究现有消费扶贫政策和方针的基础上,提出了基于大数据技术的消费扶贫可持续发展研究策略,在新一代信息技术驱动下,大数据为扶贫工作提供稳固的技术基础,文章将大数据技术应用到现有贫困和脱贫基础性数据上,通过整合、分析、统计、可视化进行观测、分析和对比.文章还提出脱贫可持续发展策略,助力持续精准脱贫,做到脱真贫、真脱贫.
Since the huge success of bone marrow transplantation technology in clinical practice,hematopoietic stem cells (HSCs) have become the gold standard for defining the properties of adult stem cells (ASCs).Here,we describe the “self-renewal,multi-lineage dif
Different psychiatric disorders share genetic relationships and pleiotropic loci to certain extent.We integrated and analyzed datasets related to major depressive disorder (MDD),bipolar disorder (BIP),and schizophrenia (SCZ) from the Psychiatric Genomics