【摘 要】
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In this paper, the mass spectrometry of three 4,20-double bonded 5/7/6 type taxoids and association of the fragmentation behavior with the hoes and positions o
【机 构】
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中国医学科学院中国协和医科大学药物研究所!北京100050,中国医学科学院中国协和医科大学药物研究所!北京100050,中国医学科学院中国协和医科大学药物研究所!北京100050,日本东邦大学药学院!
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In this paper, the mass spectrometry of three 4,20-double bonded 5/7/6 type taxoids and association of the fragmentation behavior with the hoes and positions of the substituents have been investigated by tandem mass spectromecy the results demonstrate that the loss of HOBz is the major mode of decomposition for [M+Na]+ ions of 1 and 2, while [M+H]+ ion of 3 mainly undergoes the decomposition reactions of eliminating one and two HZO molecules. After losses of all AcO and BiO groups and some OH groups, 1 and 2 form fragment ions with stable conjugated systems at ac 237, and 3 at m/z 253.
In this paper, the mass spectrometry of three 4,20-double bonded 5/7/6 type taxoids and association of the fragmentation behavior with the hoes and positions of the tote have been investigated by tandem mass spectromecy the results demonstrate that the loss of HOBz is the major mode of decomposition for [M + Na] ions of 1 and 2, while [M + H] + ion of 3 mainly undergoes the decomposition reactions of eliminating one and two HZO molecules. After losses of all AcO and BiO groups and some OH groups, 1 and 2 form fragment ions with stable conjugated systems at ac 237, and 3 at m / z 253.
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