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目的评估前列腺癌患者双睾切除术后代谢综合征患病风险。方法研究对象为100例老年男性,以美国国家胆固醇教育计划成人治疗小组第三次报告(NCEP-ATP Ⅲ)提出的诊断代谢综合征的标准。实验组为50例因前列腺癌行双睾切除术后1年以上的患者,对照组为上海市男性健康俱乐部50名年龄匹配的男性,测身高、体重、腰围、血压、空腹血糖、血脂、血清总睾酮,计算体重指数(BMI)。分析患者行双睾切除术后代谢综合征的风险是否增加。结果患者双睾切除后体重指数、腰围、甘油三脂、空腹血糖明显高于对照组(P<0.01),而血清总睾酮、高密度脂蛋白明显低于对照组(P<0.01),血压、总胆固醇、低密度脂蛋白与对照组比较差异无统计学意义(P>0.05)。结论前列腺癌患者双睾切除后1年以上,代谢综合征的风险明显增加,预示这些患者有更高的心血管疾病风险。
Objective To assess the prevalence of metabolic syndrome after prostate cancer in patients with prostate cancer. Methods The study population consisted of 100 elderly men. The criteria for the diagnosis of metabolic syndrome were presented in the third report of the National Cholesterol Education Program Adult Treatment Unit (NCEP-ATP III). The experimental group was 50 patients with prostatic cancer who underwent one-year post-testicular biopsy and the control group consisted of 50 age-matched males from Shanghai Male Health Club. The height, weight, waist circumference, blood pressure, fasting blood glucose, Total testosterone, calculated body mass index (BMI). The patient’s risk of metabolic syndrome after double-testis resection was analyzed. Results The body mass index, waist circumference, triglyceride and fasting blood glucose were significantly higher than those in the control group (P <0.01), but the levels of total testosterone and high density lipoprotein in serum were significantly lower than those in the control group (P <0.01) There was no significant difference in total cholesterol and low density lipoprotein between the two groups (P> 0.05). Conclusions The risk of metabolic syndrome is significantly increased in patients with prostate cancer more than one year after double-testosterone excision, indicating that these patients have a higher risk of cardiovascular disease.