异烟肼是最常用的抗结核药物之一,其毒副作用已为临床医师熟知,但该药与一些其他药物及食物之间产生的相互干扰作用常被忽视。对此,本文作一简要的介绍。【苯妥英钠】癫痫患者在服用苯妥英钠和苯巴比妥时若同时加服异烟肼每天300毫克时,则苯妥英钠的毒副反应发生率明显增多。有人发现过分镇静和运动失调的出现率为11％,而加服安慰剂之对照组中此毒副反应的 Isoniazid is one of the most commonly used anti-tuberculosis drugs and its side effects are well known to clinicians. However, the mutual interference between this drug and some other drugs and foods is often neglected. In this regard, this article for a brief introduction. [Phenytoin sodium] Epilepsy patients taking phenytoin sodium and phenobarbital at the same time add isoniazid plus 300 mg per day, then the phenytoin sodium toxicity increased significantly. It was found that the incidence of excessive sedation and motor disorders was 11%, while the placebo-plus control group of this toxic side effects