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目的观察新福菌素加奈达铂同步放化疗治疗鼻咽癌的急性不良反应。方法将60例Ⅱ~Ⅲ期鼻咽癌患者随机分为治疗组和对照组各30例。2组均行调强适形放射治疗。治疗组采用新福菌素联合奈达铂治疗,对照组采用奈达铂治疗。对比2组口腔黏膜、胃肠道反应、骨髓抑制、口干反应和皮肤反应等不良反应发生情况。结果治疗后在口腔黏膜反应、胃肠道反应、骨髓抑制反应等发生率高于对照组,差异有统计学意义(P<0.05)。2组口干反应、皮肤反应发生率差异无统计学意义(P>0.05)。结论新福菌素加奈达铂同步放化疗治疗鼻咽癌的不良反应主要是增加了患者口腔黏膜反应、胃肠道反应和骨髓抑制,但经对症处理及早给予护理干预后均可耐受,能大大减轻患者的痛苦,缩短住院时间。
Objective To observe the effects of neomycin-5-plus-nedaplatin concurrent chemoradiotherapy in the treatment of acute adverse reactions of nasopharyngeal carcinoma. Methods Sixty patients with stage Ⅱ ~ Ⅲ nasopharyngeal carcinoma were randomly divided into treatment group and control group, 30 cases each. 2 groups were adjusted intensity conformal radiotherapy. The treatment group with nelframycin combined nedaplatin, the control group treated with nedaplatin. The incidence of adverse reactions such as oral mucosa, gastrointestinal reaction, myelosuppression, dry mouth and skin reactions were compared between the two groups. Results The incidence of oral mucosal reaction, gastrointestinal reaction and bone marrow suppression response after treatment was higher than that of the control group (P <0.05). There was no significant difference in the incidence of dry mouth reaction and skin reaction between the two groups (P> 0.05). Conclusions The adverse reactions of neomycin-5-plus-nedaplatin concurrent chemoradiotherapy in the treatment of nasopharyngeal carcinoma mainly increase the oral mucosal reaction, gastrointestinal reaction and myelosuppression in patients, but can be tolerated after symptomatic treatment and nursing intervention as soon as possible Greatly reduce the pain of patients and shorten the hospital stay.