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目的通过分析维汉两个不同民族孕妇血清与新生儿脐血钙(Ca)、镁(Mg)、铜(Cu)、锌(Zn)、铁(Fe)5种微量元素含量的差异性,以及微量元素的差异与子痫前期病情轻重的的相关性。方法选择维汉两族正常晚期妊娠者分别56、56例、子痫前期轻度患者分别72、60例、子痫前期重度患者分别52、66例,分别测定其母血及其对应的脐血的微量元素水平。结果汉族和维吾尔两组中的正常族、子痫前期轻度组、子痫前期重度组三组之间有差异(即A1、A2、A3和B1、B2、B3),且两两比较差异有统计学意义(P<0.05);通过Spearman相关分析,不同民族的母血中铁、钙、镁、铜、锌的含量与子痫前期的病情轻重有相关性,差别有统计学意义(P<0.05),且钙、镁、锌元素与子痫前期的病情呈负相关,铁、铜元素与子痫前期的病情呈正相关,不同民族的脐血中铁、钙、镁、铜、锌的含量与子痫前期的病情轻重同样具有相关性,差别有统计学意义(P<0.05),且各个元素作用的方向相同。结论子痫前期患者的钙、镁、锌含量较正常组低,而铁、铜的含量较正常组高,且两民族间存在一定的差异性;钙、镁、锌的含量越低,子痫前期的病情越重,铁、铜的含量越高,子痫前期的病情越重。
OBJECTIVE: To analyze the differences of trace elements contents in cord blood calcium and magnesium (Mg), copper (Cu), zinc (Zn) and iron (Fe) in two different ethnic pregnant women of Uygur and Han ethnic groups The correlation between trace elements and severity of preeclampsia. Methods 56,56 normal pregnant women of both Han and Uighur groups were selected, respectively. There were 72 and 60 cases of mild preeclampsia and 52 and 66 cases of severe preeclampsia, respectively. The maternal blood and corresponding umbilical cord blood Trace element level. Results There were differences between the normal group in Han and Uygur groups, mild preeclampsia group and severe preeclampsia group (A1, A2, A3 and B1, B2, B3) Statistical significance (P <0.05). Spearman correlation analysis showed that the contents of iron, calcium, magnesium, copper and zinc in maternal blood of different ethnic groups were correlated with the severity of preeclampsia (P <0.05) ), And calcium, magnesium and zinc were negatively correlated with the condition of preeclampsia. The contents of iron, copper and element of preeclampsia were positively correlated with the content of iron, calcium, magnesium, copper and zinc in cord blood of different ethnic groups The severity of pre-eclampsia was also correlated, with a significant difference (P <0.05), and the effect of each element was the same. Conclusions The levels of calcium, magnesium and zinc in preeclampsia patients are lower than those in normal group, while the levels of iron and copper are higher than those in normal controls. There is a certain difference between the two ethnic groups. The lower the content of calcium, magnesium and zinc, the eclampsia Pre-condition of the more serious, iron, copper content is higher, the more serious the condition of preeclampsia.