论文部分内容阅读
转录组学是从RNA水平研究基因表达情况的学科。目前用于转录组数据获得和分析的方法主要有基于杂交技术的生物芯片技术和基于测序的RNA测序技术,这些方法的出现使得对细胞、组织表达谱的高通量分析成为可能,通过这些方法可以获得许多与疾病相关信息。原发性局灶节段性肾小球硬化(FSGS)是导致成人及儿童激素抵抗肾病综合征和肾衰竭的最常见原因之一,其病理生理机制至今仍不清楚。因此,有必要对其发病机制进行深入研究。近年来,数项FSGS的转录组学研究结果相继发表,进一步了解FSGS的致病机制提供了重要信息,本文就其在FSGS中的发现做一综述。
Transcriptomics is a discipline that studies gene expression at the RNA level. At present, the methods used for transcriptome data acquisition and analysis are based on hybridization-based biochip technology and sequencing-based RNA sequencing technology. The emergence of these methods makes it possible to perform high-throughput analysis of cell and tissue expression profiles. By these methods There are many disease-related information available. Primary focal segmental glomerulosclerosis (FSGS) is one of the most common causes of steroid-induced nephrotic syndrome and renal failure in adults and children, and the pathophysiological mechanisms remain unclear. Therefore, it is necessary to conduct an in-depth study of its pathogenesis. In recent years, several FSGS transcriptomics research results have been published, to further understand the pathogenic mechanism of FSGS provides important information, this article on its findings in FSGS are reviewed.