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目的:观察核不均一核糖核蛋白A2/B1(hnRNPA2/B1)在胸水转移性肺腺癌细胞和间皮细胞中的表达,评价其用于两者鉴别诊断的价值。方法:采用细胞块技术对100例胸水进行免疫组织化学检测,观察hnRNPA2/B1在肺腺癌细胞和间皮细胞中的表达。结果:hnRNPA2/B1标记肺腺癌细胞的敏感度为100%,特异度为70%。结论:检测hnRNPA2/B1对鉴别胸水肺腺癌细胞和间皮细胞很有帮助。
Objective: To observe the expression of hnRNPA2 / B1 in pleural effusion of lung adenocarcinoma cells and mesothelial cells, and to evaluate the value of hnRNPA2 / B1 for differential diagnosis. Methods: 100 cases of pleural effusion were detected by immunohistochemistry using cell block technique to observe the expression of hnRNPA2 / B1 in lung adenocarcinoma cells and mesothelial cells. Results: The sensitivity and specificity of hnRNPA2 / B1 labeled lung adenocarcinoma cells were 100% and 70% respectively. Conclusion: The detection of hnRNPA2 / B1 is helpful to identify pleural effusion of adenocarcinoma cells and mesothelial cells.