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目的:观察细辛脑联合多索茶碱治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法:将164例AECOPD患者随机分为观察组(82例)和对照组(82例),对照组予低流量吸氧、抗炎、抗感染、纠正水电解质紊乱等综合治疗,观察组在此基础上加用注射用细辛脑、多索茶碱静脉治疗。观察两组治疗前后症状、体征改善情况及血气分析变化。结果:观察组与对照组临床总有效率分别为93.9%、81.7%(P<0.05),观察组在发热、咳嗽咳痰、喘息症状消失时间,以及肺部罗音减少50%以上时间均显著短于对照组(P<0.01),在FEV1、FEV1/FVC、PEF、PaO_2、PaCO_2等指标也显著优于对照组(P<0.01)。结论:在常规治疗基础上加用细辛脑、多索茶碱可以有效提高AECOPD患者的临床疗效。
Objective: To observe the clinical efficacy of Asarum combined with doxofylline in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: One hundred and sixty-four patients with AECOPD were randomly divided into observation group (n = 82) and control group (n = 82). The control group was given low dose oxygen inhalation, anti-inflammatory, anti-infective and water- On the basis of plus injection with asarone, doxofylline vein treatment. The symptoms and signs before and after treatment and the changes of blood gas analysis were observed. Results: The total clinical effective rate in observation group and control group was 93.9% and 81.7%, respectively (P <0.05). The observation group had significant difference in the time of fever, cough and expectoration, disappearance of wheezing symptoms, and the reduction of pulmonary rales over 50% (P <0.01). The FEV1, FEV1 / FVC, PEF, PaO2, PaCO2 and other indexes were also significantly better than those of the control group (P <0.01). Conclusion: Asarone added on the basis of routine treatment, Doxofylline can effectively improve the clinical efficacy of AECOPD patients.