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目的:分析9种药物血药浓度监测结果,为临床合理用药提供参考。方法:分别采用 FPIA 法、ELISA 法和 UV 法测定9种药物的血药浓度,对7757例患者31423例次血药浓度监测结果进行比较分析。结果:9种药物31423例次血药浓度监测结果在治疗窗浓度范围内的25221例次,占总数的80.3%,小于治疗窗浓度范围的3033例次,占总数的9.6%,大于治疗窗浓度范围的3169例次,占总数的10.1%。结论:治疗药物监测能为临床合理用药提供客观的依据。
OBJECTIVE: To analyze the monitoring results of blood concentration of 9 drugs to provide reference for clinical rational drug use. Methods: The plasma concentrations of nine drugs were determined by FPIA, ELISA and UV respectively. The results of blood concentration monitoring of 31423 cases in 7757 patients were compared. Results: The monitoring results of blood concentration of 31423 cases of 9 drugs were 25221 cases in the therapeutic window concentration range, accounting for 80.3% of the total, less than the treatment window concentration range of 3033 cases, accounting for 9.6% of the total, more than the therapeutic window concentration The range of 3169 cases, accounting for 10.1% of the total. Conclusion: Therapeutic drug monitoring can provide an objective basis for clinical rational drug use.