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深入研究幼儿惊厥的各种发病机理,决定病因疗法是小儿神经学的重要课题之一。作者观察45例惊厥综合征(SC)患儿,年龄为几个月至1.5岁,其中39例为围产期脑病,3例热性惊厥,2例遗传性疾病,1例病因不明。测定这些患儿血浆和脑脊液(CSF)中游离脂肪酸(FFA)和脂质过氧化物(POL)产物——共轭二烯和席夫碱(Schiff bases)的含量,并以13例20～30岁健康成人作对照。结果表明,SC小儿血浆POL产物含量比对照组明显增高:共轭二烯增高5倍(810±150和150±24nmol/1mg脂质,以下单位略,P<0.001),席夫碱增高2倍(42.6±5.5和20±0.5%/1mg脂质,以下单位略,P<0.001)。CSF中POL产物含量是血浆的
In-depth study of various pathogenesis of convulsions in children, determine the cause of pediatric neurology is an important issue. The authors looked at 45 children with convulsive syndrome (SC) who ranged in age from a few months to 1.5 years, of whom 39 were perinatal encephalopathy, 3 febrile seizures, and 2 hereditary and 1 with unknown etiology. The contents of free fatty acid (FFA) and lipid peroxidation (POL) -conjugated dienes and Schiff bases in plasma and cerebrospinal fluid (CSF) of these children were determined. Thirteen cases of 20-30 Aged healthy adults as a control. The results showed that the content of plasma POL in SC children was significantly higher than that in the control group. The conjugated diene increased 5-fold (810 ± 150 and 150 ± 24nmol / 1mg lipid, the following units slightly, P <0.001) (42.6 ± 5.5 and 20 ± 0.5% / 1 mg lipid, the following units omitted, P <0.001). The amount of POL product in CSF is plasma