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目的研究Tibolone对去势裸鼠人子宫内膜癌皮下移植瘤生长及转移的影响,探讨Tibolone治疗子宫内膜癌的安全性.方法建立去势裸鼠人子宫内膜癌皮下移植瘤模型,比较Tibolone灌胃组和对照组给药前后肿瘤体积变化和转移状况.结果Tibolone灌胃组和安慰剂组裸鼠子宫内膜癌皮下移植瘤体积增加值相同(1.976±1.350)mm3和(2.217±1.071)mm3,P=0.879;Tibolone灌胃组(35 d)后,没有引起肿瘤转移.结论Tibolone不刺激裸鼠人子宫内膜癌皮下移植瘤生长及转移
Objective To study the effect of Tibolone on the growth and metastasis of subcutaneously transplanted human endometrial carcinoma in nude mice and to explore the safety of Tibolone in the treatment of endometrial carcinoma.Methods To establish a subcutaneous xenograft model of human endometrial carcinoma in ovariectomized nude mice Tibolone group and control group before and after administration of tumor volume changes and metastasis status.Results Tibolone intragastric administration group and placebo group nude mice subcutaneously implanted tumor endometrial tumor volume increases the same value (1.976 ± 1.350) mm3 and (2.217 ± 1.071 ) mm3, P = 0.879; Tibolone did not induce tumor metastasis after intragastric administration (35 d) .Conclusion Tibolone does not stimulate the growth and metastasis of subcutaneous xenografts in nude mice with endometrial carcinoma