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《Med Post》1984;21(7):32. 美国内布拉斯加的列克顿大学附属医学院的Henry Lynch称,看来已发现家族性卵巢癌的生物化学和遗传学标记,对于易患卵巢癌者的遗传咨询具有一定的价值。Lynch在第二届国际肿瘤标记物会议上说,在某些病例中,标记物可能加强了以下的建议:凡有卵巢癌的高度遗传危险性的妇女,应作预防性双侧卵巢切除术。对于三个家族的四代健康史作了分析,证明卵巢癌的发病率异常高的家族中多数成员体外细胞试验显示出超二倍性(培养中的皮肤细
“Med Post” 1984; 21 (7): 32. Henry Lynch of the Affiliated School of Medicine of the University of Leyton, Nebraska, USA, appears to have found biochemical and genetic markers of familial ovarian cancer Genetic counseling for people with ovarian cancer has some value. Lynch at the 2nd International Tumor Markers Conference said that in some cases markers may reinforce the following recommendations: Women with a high genetic risk of ovarian cancer should be treated for prophylactic bilateral ovariectomy. An analysis of the fourth generation’s health histories of the three families proves that in vitro cell tests of most members of an unusually high incidence of ovarian cancer show hyperploidy (skin thinning in culture