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目的:分析口腔扁平苔藓患者免疫功能与临床特征的相关性。方法:选取102例口腔扁平苔藓患者,其中38例网纹型口腔扁平苔藓患者,64例充血糜烂型口腔扁平苔藓患者,检测所有患者的免疫功能状况。结果:口腔扁平苔藓患者的CD3~+、CD4~+、Ig A、C3水平降低,CD19~+、Ig G、Ig M、CH50水平升高,差异具有统计学意义(P<0.05);对于网纹型口腔扁平苔藓患者的CD16~++56~+、CD4~+/CD8~+水平降低,充血糜烂型口腔扁平苔藓患者的CD8+水平降低,差异具有统计学意义(P<0.05);充血糜烂型口腔扁平苔藓患者的CD3~+、CD8~+水平均显著低于网纹型口腔扁平苔藓,而CD4~+/CD8~+水平显著高于网纹型口腔扁平苔藓,差异具有统计学意义(P<0.05)。结论:口腔扁平苔藓患者存在不同程度的免疫功能紊乱,体液免疫功能亢进为主;不同类型的口腔扁平苔藓患者的免疫功能状况存在差异性。
Objective: To analyze the correlation between immune function and clinical features in oral lichen planus. Methods: A total of 102 patients with oral lichen planus were selected, including 38 patients with oral lichen planus and 64 patients with congestive erosive oral lichen planus. The immune function of all patients was examined. Results: The levels of CD3 ~ +, CD4 ~ +, IgA, C3 in oral lichen planus were decreased and the levels of CD19 ~ +, Ig G, Ig M and CH50 were increased in the patients with oral lichen planus (P <0.05) CD16 ~ +56 ~ +, CD4 ~ + / CD8 ~ + levels in patients with oral lichen planus were decreased, and CD8 + levels in patients with congestive erosive oral lichen planus decreased, with statistical significance (P <0.05) The levels of CD3 ~ + and CD8 ~ + in patients with oral lichen planus were significantly lower than that of the oval lichen planus, while the levels of CD4 ~ + / CD8 ~ + were significantly higher than those of the oval lichen planus P <0.05). CONCLUSIONS: There are different degrees of immune dysfunction and humoral immune function in patients with oral lichen planus. There are differences in immune function among different types of oral lichen planus.