应用RIA方法检测了31例类风湿关节炎(RA),16例强直性脊柱炎(AS)患者及46例正常人血清透明质酸(HA)含量,发现RA患者HA含量明显高于AS患者和正常人(p<0.001),AS患者和正常人间HA无明显差别(p>0.05);同时还发现RA患者血清HA含量与累及关节数、关节肿胀指数和压痛指数以及血小板呈正相关,与白蛋白、球蛋白比值呈负相关。结果提示血清HA含量有可能作为早期鉴别RA和AS的一种参考指标,且可以作为判断RA病情活动性的一项临床检测指标。 RIA method was used to detect the content of HA in serum of 31 patients with rheumatoid arthritis (RA), 16 patients with ankylosing spondylitis (AS) and 46 healthy subjects. The HA content in RA patients was significantly higher than that in patients with AS and There was no significant difference between normal subjects (p <0.001) and normal subjects (p> 0.05). The serum HA levels in patients with RA were also found to be positively correlated with the number of involved joints, joint swelling index and tenderness index and platelets, , Globulin ratio was negatively correlated. The results suggest that serum HA levels may be used as a reference index for early identification of RA and AS, and may be used as a clinical indicator to determine the activity of RA.