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目的探讨胎儿宫内生长受限(FGR)的影响因素,为临床预防治疗FGR提供借鉴。方法对2010年1月-2016年1月余杭区第一人民医院收治的9 327名产妇为研究对象,确诊为FGR患者275例,采用统一的调查收集FGR发生的相关因素,包括产妇一般情况、既往疾病史情况和妊娠情况等,采用单因素及多因素Logistic回归分析,探讨FGR发病的有关危险因素。结果 FGR发生率为2.95%。单因素分析显示,FGR与产妇身高、产妇吸烟、妊娠期高血压疾病、胎盘异常、脐带血流异常、低蛋白血症、孕期感染等因素相关(均P<0.05)。Logistic多因素回归分析发现产妇吸烟(OR=1.724,P=0.011)、低蛋白血症(OR=2.833,P=0.023)、妊娠期高血压疾病(OR=1.659,P=0.018)、脐带血流异常(OR=3.624,P=0.016)、胎盘异常(OR=2.181,P=0.012)是影响FGR的独立危险因素。结论 FGR的发病是多种因素共同作用的结果,一旦发现各种相关因素,应当采取积极的应对措施。
Objective To investigate the influencing factors of fetal intrauterine growth restriction (FGR) and provide references for clinical prevention and treatment of FGR. Methods A total of 9 327 maternal women admitted to the First People’s Hospital of Yuhang District between January 2010 and January 2016 were enrolled in the study. 275 patients were diagnosed as FGR. The related factors of FGR, including general maternal status, Past disease history and pregnancy status, using single factor and multivariate Logistic regression analysis to explore the risk factors associated with FGR. Results The incidence of FGR was 2.95%. Univariate analysis showed that FGR was correlated with maternal smoking, maternal smoking, gestational hypertension, abnormal placenta, abnormal umbilical cord blood flow, hypoalbuminemia and pregnancy infection (all P <0.05). Logistic regression analysis showed that maternal smoking (OR = 1.724, P = 0.011), hypoproteinemia (OR = 2.833, P = 0.023), hypertensive disorder complicating pregnancy (OR = 1.659, P = 0.018) Abnormalities (OR = 3.624, P = 0.016), placental abnormalities (OR = 2.181, P = 0.012) were independent risk factors for FGR. Conclusions The incidence of FGR is the result of the combination of many factors. Once relevant factors are found, a positive response should be taken.