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当高血压需要两种药物治疗时,β阻滞剂和α阻滞剂并用是最佳的联合。因为两者作用不同,具有外周作用的α阻滞剂可使β阻滞剂的不良作用减小到最低限度。 165例原发性高血压患者,卧位舒张压105～125mmHg,口服β阻滞剂阿替洛尔每日50mg,8周后仍有110例卧位舒张压95～110mmHg。随机给其中43例加服α~1阻滞剂特拉唑嗪,起始量1mg每日4次,2周内逐渐达到极量(10mg每日4次)或使卧位舒张压下降至90mmHg以下,共治疗10
When high blood pressure requires two drugs, the combination of beta blockers and alpha blockers is the best combination. Because of the difference between the two effects, with the role of peripheral α blockers can block the adverse effects of β blockers to a minimum. In 165 patients with essential hypertension, the diastolic blood pressure in the supine position was 105-125mmHg. Atenolol, a beta-blocker, was administered daily at a dose of 50mg. After 8 weeks, 110 supine diastolic pressure was 95-110mmHg. Of which 43 cases were randomized to take α-1 blocker terazosin, the initial amount of 1mg 4 times a day, gradually reached the limit within 2 weeks (10mg 4 times a day) or supine diastolic blood pressure dropped to 90mmHg The following, a total of 10 treatment