有关口腔颌面部肿瘤发生机制尚无统一认识。近年来,人们认识到癌基因的激活和抑癌基因的失活与肿瘤的发生﹑发展有密切关系。研究证实,口腔颌面部肿瘤与多个基因和抑癌基因有关。p53基因是迄今为止发现的与人类肿瘤相关性最高的抑癌基因[1],其在细胞周期调控、细胞生长抑制、肿 There is no uniform understanding of the pathogenesis of oral and maxillofacial tumors. In recent years, people have realized that oncogene activation and tumor suppressor gene inactivation are closely related to the occurrence and development of tumors. Studies confirm that oral and maxillofacial tumors with multiple genes and tumor suppressor genes. The p53 gene is by far the most tumor suppressor gene associated with human tumors [1], which has a significant role in cell cycle regulation, cell growth inhibition, swollen