补阳还五汤联合悬吊运动训练治疗脑梗死合并下肢偏瘫临床研究

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目的:评价补阳还五汤联合悬吊运动训练治疗脑梗死合并下肢偏瘫的疗效及对下肢功能的影响。方法:将符合入选标准的2017年1月-2021年2月本院94例脑梗死合并下肢偏瘫患者采用随机数字表法分为2组,每组47例。对照组给予悬吊运动训练干预,观察组在对照组基础上服用补阳还五汤。2组均治疗6周,随访3个月。分别于治疗前后进行中医证候评分,采用美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评估神经功能受损程度,Fuglmeyer下肢运动功能量表(Fugl-Meyer Assessment,FMA)评估下肢功能,Berg平衡功能评分(Berg Balance Scale,BBS)评估平衡功能,Barthel指数(Barthel Index,BI)评估日常生活能力;采用全自动血液流变分析仪检测全血黏度高切、血浆黏度及红细胞压积,全自动分析仪检测血浆TC、TG、LDL-C水平;随访3个月,采用Rankin量表(mRS)评估患者预后,记录治疗期间的不良反应。结果:观察组治疗后中医证候积分及NIHSS评分均低于对照组(n t值分别为5.35、4.54,n P值均n <0.01),FMA、BBS、BI评分均高于对照组(n t值分别为3.40、3.10、7.57,n P值均n <0.01);全血黏度高切、血浆黏度及红细胞压积均低于对照组(n t值分别为2.94、3.81、4.23,n P<0.05或n P<0.01),TC、TG及LDL-C水平均低于对照组(n t值分别为4.10、4.27、3.61,n P值均n <0.01)。观察组预后良好率为74.47%(35/47)、对照组为51.06%(24/47),2组比较差异有统计学意义(n χn 2=5.51,n P=0.019)。n 结论:补阳还五汤联合悬吊运动训练可有效缓解脑梗死合并下肢偏瘫患者的临床症状、恢复下肢功能,提升日常生活能力,改善预后。“,”Objective:To explore the curative effect of Buyang Huanwu Decoction combined with suspension exercise training for the patients with cerebral infarction combined and lower limb hemiplegia.Methods:According to random number table method, 94 patients with cerebral infarction and lower limb hemiplegia meeting the inclusion criteria were divided into the control group and the observation group between January 2017 and February 2021, 47 in each group. The control group was treated with suspension exercise training, while observation group was additionally treated with Buyang Huanwu Decoction on the basis of the control group treatment. All were treated for 6 weeks and then followed up for 3 months. Before and after treatment, the Traditional Chinese Medicine (TCM) syndromes scores were recorded. The severity of nerve function injury was evaluated by National Institutes of Health Stroke Scale (NIHSS). The lower limb function was evaluated by Fugl-Meyer Assessment (FMA). The balance function was evaluated by Berg Balance Scale (BBS). The activities of daily life were assessed by Barthel Index (BI). The whole blood high shear viscosity, plasma viscosity and hematocrit were detected by full-automatic hemorheology analyzer. The levels of plasma total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) were detected by full-automatic analyzer. All were followed up for 3 months. The prognosis of patients was assessed by modified Rankin scale (mRS). The adverse reactions during treatment were recorded.Results:After treatment, scores of TCM syndromes and NIHSS in observation group were significantly lower than those in control group (n t=5.35, 4.54, n P<0.01), while scores of FMA, BBS and BI were significantly higher than those in control group (n t=3.40, 3.10, 7.57, n P<0.01). The whole blood high-shear viscosity, plasma viscosity and hematocrit in observation group were significantly lower than those in control group (n t=2.94, 3.81, 4.23, n P<0.05 orn P<0.01), and levels of TC, TG and LDL-C were significantly lower than those in control group (n t=4.10, 4.27, 3.61, n P<0.01). The differences in good prognosis rate between observation group and control group were statistically significant [74.47% (35/47)n vs. 51.06% (24/47); n χ2=5.51, n P=0.019].n Conclusion:The Buyang Huanwu Decoction combined with suspension exercise training can relieve clinical symptoms, recover lower limb function, improve activities of daily life and prognosis in cerebral infarction combined with lower limb hemiplegia.
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