Characterization and DNA Interaction of Lanthanide Complexes Based on Thiourea Ligand

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Three isostructural lanthanide complexes,namely[Ln(L)3·CH3OH](Ln = Tb(1),Dy(2),Ho(3),HL= N-(pyridin-2-ylcarbamothioyl)benzamide),were successfully synthesized and characterized by IR,UV,elemental analysis,single-crystal X-ray diffraction and DNA-biding analysis.X-ray single-crystal diffractions show that the family of lanthanide complexes crystallizes in monoclinic C2/c space group.Each lanthanide atom is coordinated with three carbonyl-O atoms,three pyridyl-N atoms and three imine-N atoms from three distinct L-1 ligands,forming a distorted tricapped trigonal prism.The binding properties of complexes with ct-DNA were studied by simulating the physiological environment of human body.The results suggest that compounds could bind with ct-DNA through interaction under a spontaneous process.
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