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本文分析四川省1982~1986年监测的294例无脑畸形和165例脊柱裂畸形资料,算得两种畸形出生高峰日期与其母亲末次月经高峰日期的间隔等于平均妊期,经在IBM-PC微机上应用Von Mises分布模拟,获得了同样的结论。证实了Elwood于1980年提出的推断。应用中可只用出生高峰日期减去平均妊期推算末次月经高峰日期,为研究出生缺陷发生率的季节性波动提供了一个简易可行的方法。
This paper analyzes the data of 294 cases of anencephaly and 165 cases of spina bifida malformation monitored in Sichuan from 1982 to 1986. The interval between the peak birth date and the mother’s last menstrual peak date is equal to the average pregnancy period, and is calculated on an IBM-PC microcomputer. Using the Von Mises distribution simulation, the same conclusion was obtained. The conclusion made by Elwood in 1980 was confirmed. The application can use only the peak birth date minus the average pregnancy period to calculate the last menstrual peak date, which provides a simple and feasible method for studying seasonal fluctuations in the incidence of birth defects.