目的总结原发性十二指肠癌临床特点、诊治方法及预后。方法回顾性分析10例原发性十二指肠癌患者临床资料。结果本组患者以腹痛、黄疸、腹胀、呕吐为主要临床症状;胃镜、十二指肠镜检查以及磁共振胰胆管造影、CT和B超等检查有助于明确诊断;手术治疗6例,术后1a生存4例,3a生存2例;未行手术治疗4例,1a内均死亡。结论原发性十二指肠癌症状无特异性,胰十二指肠切除手术可作为首选治疗方法。 Objective To summarize the clinical features, diagnosis and treatment methods and prognosis of primary duodenal cancer. Methods The clinical data of 10 patients with primary duodenal cancer were retrospectively analyzed. Results The patients with abdominal pain, jaundice, abdominal distension and vomiting as the main clinical symptoms; gastroscopy, duodenoscopy and magnetic resonance cholangiopancreatography, CT and B ultrasonography can help confirm the diagnosis; surgery in 6 cases, After la survival in 4 cases, 3a survival in 2 cases; no surgical treatment in 4 cases, 1a were dead. Conclusion The symptoms of primary duodenal cancer are nonspecific. Pancreaticoduodenectomy may be the first choice of treatment.