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目的评价胺碘酮联合厄贝沙坦治疗阵发性房颤的临床疗效。方法 78例阵发性房颤的患者随机分为治疗组(胺碘酮+厄贝沙坦)和对照组(胺碘酮),口服给药,疗程均为1年。比较治疗后2组窦性心律维持率和左心房内径的变化。结果治疗组窦性心率维持率明显高于对照组(P<0.05),左心房内径亦有显著性缩小(P<0.05)。结论胺碘酮联合厄贝沙坦治疗阵发性心房颤动维持窦性心率的疗效优于单用胺碘酮,且能抑制左心房扩大。
Objective To evaluate the clinical efficacy of amiodarone combined with irbesartan in the treatment of paroxysmal atrial fibrillation. Methods A total of 78 patients with paroxysmal atrial fibrillation were randomly divided into treatment group (amiodarone + irbesartan) and control group (amiodarone), which were given orally for 1 year. The changes of sinus rhythm maintenance rate and left atrial diameter were compared between the two groups after treatment. Results The maintenance rate of sinus rhythm in treatment group was significantly higher than that in control group (P <0.05), and the diameter of left atrium was also significantly reduced (P <0.05). Conclusion Amiodarone combined with irbesartan in patients with paroxysmal atrial fibrillation to maintain sinus heart rate is superior to single use of amiodarone, and can inhibit the expansion of the left atrium.