论文部分内容阅读
目的检测血清总胆汁酸(TBA)水平,探讨血清总胆汁酸测定在足月新生儿黄疸诊治中的临床意义。方法选取82例临床资料完整,诊断为新生儿黄疸的患儿为研究对象,分为重度黄疸组(A组)、轻度黄疸组(B组)、生理黄疸组(C组),检测各组患儿血清中总胆汁酸(TBA)的水平及其他肝功能相关指标并进行比较。结果 1A组及B组TBA、TBTL(总胆红素)、DBTL(直接胆红素)、ALT(丙氨酸转氨酶)水平显著高于C组,差异有统计学意义(P<0.05);B组与C组GGT(γ-谷氨酰转肽酶)水平比较差异无统计学意义(P>0.05)。2A,B两组TBA水平与TBTL,DBTL,GGT,ALT各项肝功能指标有直线相关关系。3A,B组治疗前TBA,TBTL水平较治疗后明显下降,差异有统计学意义(P<0.05),但A组TBA及TBIL消退时间较B组长,差异有统计学意义(P<0.05)。结论血清总胆汁酸测定在新生儿黄疸的诊断中具有重要临床意义,有利于新生儿黄疸的早期诊治及预后。
Objective To determine the serum total bile acid (TBA) level and to explore the clinical significance of serum total bile acid in diagnosis and treatment of full-term neonatal jaundice. Methods Totally 82 children with jaundice diagnosed as neonatal jaundice with complete clinical data were selected and divided into severe jaundice group (group A), mild jaundice group (group B) and physiological jaundice group (group C) Children with serum total bile acid (TBA) levels and other indicators of liver function and compared. Results The levels of TBA, TBTL, DBTL and ALT in group 1A and group B were significantly higher than those in group C (P <0.05); B Group G and GGT (γ-glutamyl transpeptidase) levels were no significant difference (P> 0.05). The levels of TBA in 2A and B groups were linearly correlated with the indexes of liver function in TBTL, DBTL, GGT and ALT. The levels of TBA and TBTL in 3A and B groups decreased significantly after treatment compared with those in the control group (P <0.05), but the time to resolution of TBA and TBIL in group A was longer than that in group B (P <0.05) . Conclusion The determination of serum total bile acid has important clinical significance in the diagnosis of neonatal jaundice, which is benefit for the early diagnosis and prognosis of neonatal jaundice.