3例年龄3.3～3.9岁的男孩,均患有青春期早熟症,以往用过类似促性腺释放激素作用的药物治疗无效,作者使用 ketoconazole 治疗1年,疗效满意。该药是一种抗真菌药,近年来经体内、外的实验,通过血清17羟黄体酮水平的改变,表明在类固醇的羟化过程中,该药主要相对地选择作用于第17～20碳位置上的裂解,使睾丸酮的生物合成发生障碍。 Three boys aged 3.3- 3.9 years had prematurity adolescence. In the past, drugs similar to the gonadotrophic releasing hormone were ineffective. The authors treated ketoconazole for 1 year and were satisfied with the results. The drug is an antifungal drug, in recent years through in vivo and in vitro experiments, changes in serum progesterone 17 levels, indicating that in the hydroxylation of steroids, the drug is relatively the main choice of the first 17 to 20 carbon Lysis of the position, the testosterone biosynthesis disorder.