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三苯氧胺常作为乳癌术后辅助内分泌治疗药物之一,亦用于子宫内膜癌治疗。但Fornander等报告,乳癌术后单独采用三苯氧胺,子宫内膜癌发生率增加。因此,对闭经后乳癌术后患者单独应用三苯氧胺时,应常规作子宫内膜细胞学诊断,以确认三苯氧胺是否具有雌激素样作用。作者首先报告4例乳癌术后长期服用三苯氧胺患者(服用时间2～8年)而发生子宫内膜癌,推测三苯氧胺长期服用引起雌激素
Tamoxifen is often used as an adjuvant endocrine therapy for breast cancer and is also used for the treatment of endometrial cancer. However, Fornander et al. reported that tamoxifen was used alone after breast cancer and the incidence of endometrial cancer increased. Therefore, when tamoxifen alone is applied to patients after postmenopausal breast cancer surgery, endometrial cytology should be routinely diagnosed to determine whether tamoxifen has estrogen-like effects. The authors first reported on the occurrence of endometrial cancer in 4 patients with long-term administration of tamoxifen after 2 weeks of breast cancer operation. It is assumed that tamoxifen causes estrogen after long-term use.