【摘 要】
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INTRODUCTIONrnAlthough the human skeleton can often repair simple fractures, nonhealing fractures and large-scale critical-sized defects are still major clinical challenges.1–2 Typically, after a bone fracture, a hematoma forms, followed shortly by an acu
【机 构】
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University of Southern California,Keck School of Medicine,Department of Stem Cell Biology and Regene
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INTRODUCTIONrnAlthough the human skeleton can often repair simple fractures, nonhealing fractures and large-scale critical-sized defects are still major clinical challenges.1–2 Typically, after a bone fracture, a hematoma forms, followed shortly by an acute inflammatory phase. Skeletal progenitors become active, move to the injury site, and differentiate (reviewed in ref. 3).
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