自１９９７年５月１０日至１９９８年５月１０日，我院门诊在随机诊疗中收集较典型的外阴黑色病变１１例，发病率为０２％（１１／５４００）。１１例病理组织学检查、光镜、电镜结果一致，均为间变Ⅰ～Ⅱ级，归属于外阴上皮内瘤样改变（ＶＩＮ）。同时进行ＰＣＲ法检测乳头瘤病毒（ＨＰＶ）１６、１８型ＤＮＡ，其结果表明，ＨＰＶ１６ＤＮＡ的阳性率占８１８％，ＨＰＶ１８ＤＮＡ阳性率为９１％。上述结果证明，外阴黑色病变的病因是人乳头瘤病毒（ＨＰＶ１６，１８型）感染为主的疾病 From May 10, 1997 to May 10, 1998, outpatient clinics in our hospital collected 11 cases of typical vulvar black lesions in randomized treatment, the incidence was 0.2% (11/5400). Eleven cases of pathological examination, light microscope, electron microscopy results are the same Ⅰ ~ Ⅱ between the change, belonging to vulvar intraepithelial neoplasia change (VIN). At the same time, HPV 16 and 18 were detected by PCR. The results showed that the positive rate of HPV16 DNA was 818% and the positive rate of HPV18 DNA was 91%. The above results prove that the cause of vulvar black lesions is the infection of human papillomavirus (HPV16,18 type) -based diseases