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Objective: To observe the effect of Pingchuan granule on the number of type Ⅱ innate lymphocytes (ILC2) and M2 polarization of macrophages in the lung tissue of asthmatic mice; Methods: Ovalbumin sensitized and challenged asthmatic mouse models were established, and then Pingchuan granules or IL-33 neutralizing antibody were given to intervene. The pathological morphology of lung tissue was observed by HE, PAS and Masson staining, and the expressions of IL-4, IL-5, IL-13 and IL-33 in BALF and lung tissue were detected by ELISA and qRT-PCR, Flow cytometry was used to detect the number of type Ⅱ innate lymphocytes and type M2 macrophages in lung tissue. Western blot was used to detect the protein expression levels of ST-2, FIZZ1 and Arg-1 in lung tissue; Results: Compared with the control group, the inflammation score, PAS score and collagen staining area of the model group were significantly increased, the expressions of IL-4, IL-5, IL-13 and IL-33 in BALF and lung tissue were significantly increased, the number of ILC2 and M2 macrophages, the expression of ST-2, FIZZ1 and Arg-1 protein in lung tissue were significantly increased, and the differences were statistically significant (P<0.05); Compared with the model group, Pingchuan granule could significantly reduce the inflammation score, PAS score and collagen staining area of asthmatic mice, down-regulate the expression of IL-4, IL-5, IL-13 and IL-33 in BALF and lung tissue, reduce the number of ILC2 and M2 macrophages, and the expression of ST-2, FIZZ1 and Arg-1 protein in lung tissue (P<0.05); Conclusion: Pingchuan granule improve the airway remodeling of asthma by inhibiting the polarization of M2 macrophages mediated by ILC2.