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目的：为尼群地平防治肺缺血再灌注损伤提供实验依据。方法：采用大鼠肺在体缺血再灌注模型，将３６只大鼠随机分成损伤对照组和尼群地平处理组，各组在缺血后、再灌注２ｈ、４ｈ后处死动物，通过大体、光镜和透射电镜观察及肺干／湿重比值测定，观察肺缺血再灌注损伤早期形态学变化。结果：肺缺血再灌注损伤早期出现以肺泡毛细血管膜通透性增加为特征的组织细胞损害，肺实质细胞胞浆和细胞器肿胀、空化变性、核淡染，Ⅱ型上皮细胞板层体排空、数目减少。尼群地平处理后，损伤肺组织形态变化减轻。结论：尼群地平对肺缺血再灌注损伤具有保护作用
Objective: To provide experimental evidence for the prevention and treatment of nitrendipine on lung ischemia-reperfusion injury. Methods: Thirty-six rats were randomly divided into injury control group and nitrendipine treatment group. The rats in each group were sacrificed 2h and 4h after ischemia, Light and transmission electron microscopy and lung dry / wet weight ratio were measured to observe the early morphological changes of lung ischemia-reperfusion injury. Results: In the early stage of lung ischemia-reperfusion injury, the histopathological changes characterized by increased permeability of alveolar capillaries, swelling of cytoplasm and organelles of the lung parenchyma, cavitation degeneration, light nuclear staining, type II epithelial cell laminae Empty, reduce the number. After treatment with nitrendipine, the morphological changes of lung tissue were lessened. Conclusion: Nitrendipine has a protective effect on lung ischemia-reperfusion injury