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为了说明肝硬化时的糖代谢与氨代谢的关系,对肝硬化患者糖负荷试验时的血氨变化与血中胰岛素的关系进行了研究。对象及方法:肝硬化患者35例(非代偿性25例,代偿性10例),原发性糖尿病11例,健康者10例作为对照。于早晨空腹时服葡萄糖100g,在服糖前及负荷后30、60、90、120、180分钟分别抽取静脉血测定血氨(奥田—藤井氏法)、血糖(OTB 法)、血中胰岛素(二抗体法免疫胰岛素以下简称IRI)。把糖负荷后的血氨值与负荷前对比,根据其增减率将血氨分为三个型,即高于负荷前值20%以上者为A 型,低于负荷前值20%以下者为B 型,波动在上、下20%以内者为C 型。糖耐量异常的判断,则根据日本糖尿病学会的标准,即IRI 在六次测定中有一次超过188μu/ml(正常的最高值即平均值加2倍标准差)或六次测定值的总和超过
In order to illustrate the relationship between glucose metabolism and ammonia metabolism during cirrhosis, the relationship between serum ammonia and blood insulin in patients with cirrhosis was investigated. PARTICIPANTS AND METHODS: 35 patients with cirrhosis (25 non-compensatory and 10 compensated), 11 patients with primary diabetes and 10 healthy controls were used as controls. Serum ammonia (Okuda-Fujii’s method), blood sugar (OTB method), blood insulin (before taking the fasting fasting glucose 100g, before taking the sugar and 30,60,90,120,180 minutes after the load) Second antibody immunization of insulin hereinafter referred to as IRI). The blood ammonia load after the sugar load contrast with the load, according to the rate of change will be divided into three types of blood ammonia, that is, more than 20% of the load before the above is A type, less than 20% For the B type, fluctuations in the upper and lower 20% of those who are C-type. According to the standard of the Japanese Diabetes Association, the IRI exceeds 188 μu / ml once in six determinations (normal maximum value plus two times standard deviation) or the sum of the six determinations exceeds