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建立经动脉逆行左室插管转流模型,观察了5种不同转流率(BFR)对犬正常及急性缺血心脏的辅助效应。结果表明:各BFR均能增加全心输出量(TCO),冠状窦引流量(CSBF)及降低心肌缺血后左房压和左室舒张末压(LVEDP)。以75%BFR辅助效果最为明显。85%以上BFR时,TCO,CSBF并无进一步增加,且室间隔增厚率,运动幅度及右室面积变化率均有明显下降,右室舒张末压(RVEDP)增大。提示大流量转流对改善心功能并非必需,且对缺血心脏的右心功能有潜在的损害效应。
A retrograde left ventricular cannulation and transthoracic flow model was established and the effects of five kinds of BFRs on normal and acute ischemic heart were observed. The results showed that each BFR increased total output (TCO), coronary sinus drainage (CSBF) and decreased left atrial pressure and left ventricular end-diastolic pressure (LVEDP) after myocardial ischemia. 75% BFR auxiliary effect most obvious. TCO and CSBF did not increase more than 85% BFR, and ventricular septal thickening rate, exercise amplitude and right ventricular area change rate were significantly decreased, and right ventricular end diastolic pressure (RVEDP) increased. Suggesting that large flow diversion is not necessary to improve cardiac function, and has potential damaging effects on right heart function in ischemic heart.