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目的研究手术前后人脑胶质瘤患者血清内内皮抑素(ES)的表达程度和临床意义。方法检测术前术后脑胶质瘤患者体内血清中内皮抑素的表达程度,采用ELISE方法检测46例患者。于此同时抽取9例健康人的血清标本来进行正常对照。结果在健康人的血清内,ES平均的含量在19.26ng/ml到22.22ng/ml之间。而神经胶质瘤患者在手术之前体内血清中ES的平均含量可达21.00ng/ml到32.26ng/ml之间,而且胶质瘤的恶性程度越高,患者血清内ES的含量也越高。结论术后5、6 d之后,胶质瘤患者血清内ES含量平均在17.38ng/ml到26.16ng/ml之间,比手术前明显偏低。结论内皮抑素在血清中的含量可以反映出肿瘤生长的情况,并且还和肿瘤的恶变程度和患者的预后有着关系。
Objective To study the expression and clinical significance of endostatin (ES) in human gliomas before and after surgery. Methods The levels of endostatin in the serum of patients with glioma before operation were detected, and 46 patients were detected by ELISE. At the same time, nine healthy human serum samples were taken for normal control. Results In healthy human serum, the average content of ES was between 19.26 ng / ml and 22.22 ng / ml. The glioma patients before surgery in vivo serum ES in the average content of up to 21.00ng / ml to 32.26ng / ml, and the higher the degree of glioma malignancy, the patient’s serum ES content is higher. Conclusions After 5 and 6 days, the serum levels of ES in patients with gliomas average between 17.38ng / ml and 26.16ng / ml, which are obviously lower than those before operation. Conclusions The content of endostatin in serum can reflect the growth of tumor and is also related to the malignant degree of tumor and the prognosis of patients.