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为探讨氨哮素对人体失神经骨骨各肌内胶原代谢的影响，采用安慰剂对照的随机双盲研究法，对７１例因臂丛神经损伤而致肌皮神经功能完全丧失的患者，给予氨哮素或安慰剂６０μｇ，每天２次，治疗３个月。实验前、后均行肱二头肌活检，活检肌肉作Ⅰ型、Ⅳ型胶原的免疫组织化学染色和图像分析。结果表明，氨哮素治疗组肌内膜中Ⅰ型胶原明显低于安慰剂组，Ⅳ型胶原纤维的增生明显少于安慰剂组（Ｐ＜０．０５）。证明，氨哮素能抑制失神经骨骨各肌内胶原的增生
In order to investigate the effect of Ammunoxastrone on intramuscular collagen metabolism in denervated human bone, a placebo-controlled randomized double-blind study was conducted in 71 patients with complete loss of muscular nerve function due to brachial plexus injury Amilormin or placebo 60μg, 2 times a day for 3 months. Biceps femoral biopsy and biopsy were performed before and after the experiment. Immunohistochemical staining and image analysis of type I and type IV collagen were performed. The results showed that the type Ⅰ collagen in the amniotic membrane in the amikacin treatment group was significantly lower than that in the placebo group. The proliferation of type Ⅳ collagen fibers was significantly less than that in the placebo group (P <0.05). Prove that ammonia Astragalus can inhibit the denervated bone collagen in the proliferation of intramuscular