论文部分内容阅读
在生物体的发育和自稳态的维持中,细胞凋亡发挥了重要作用。细胞凋亡有助于清除发育过程中多余和异常的细胞,以维持细胞增殖和凋亡的动态平衡,保证神经管的正常发育。在神经管发育期间,细胞凋亡容易受自身遗传、母体营养、环境理化因素的影响,这些因素可直接或间接干扰凋亡基因的正常表达,使细胞凋亡发生紊乱,打破细胞增殖和凋亡的动态平衡,最终影响机体的正常发育,使神经管闭合异常,导致神经管畸形的发生。综述细胞凋亡在神经管发育过程中的作用。
Apoptosis plays an important role in the development of organisms and the maintenance of homeostasis. Apoptosis helps clear excess and abnormal cells during development to maintain the dynamic balance of cell proliferation and apoptosis and ensure the normal development of neural tube. During the development of neural tube, apoptosis is easily affected by their own inheritance, maternal nutrition and environmental physicochemical factors, which may directly or indirectly interfere with the normal expression of apoptotic genes, disrupt apoptosis and break down cell proliferation and apoptosis Of the dynamic balance, and ultimately affect the normal development of the body, so that neural tube closure abnormalities, resulting in the occurrence of neural tube defects. The role of apoptosis in neural tube development is reviewed.