心钠素(简称ANP)是近几年发现的由心房肌细胞产生并分泌的一类多肽类激素,具有强大的利钠、利尿和舒张外周血管的作用。1986年,Baertschi等用缺氧液体灌流大鼠和兔的离体心脏,发现ANP的释放增多。同年,Mckenzie等发现将大鼠暴露于慢性缺氧(0.5atm)状态下连续21天,血浆心钠素明显升高。但是,有关急性缺氧时心钠素的改变及其 Atrial natriuretic peptide (ANP) is a class of peptide hormones produced and secreted by atrial myocytes in recent years. It has strong sodium, diuretic and diastolic peripheral blood vessels. In 1986, Baertschi et al. Perfused rat and rabbit isolated hearts with hypoxic fluid and found that ANP release increased. In the same year, Mckenzie et al found that rats exposed to chronic hypoxia (0.5atm) for 21 consecutive days, plasma atrial natriuretic peptide was significantly increased. However, the change of atrial natriuretic peptide in acute hypoxia and its