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目的:观察乳腺癌患者术前新辅助化疗中应用排毒汤对化疗过程中毒副反应的预防效果。方法:选取常州市第七人民医院及上海国际和平妇幼保健院2012年4月至2015年1月收治的100例确诊乳腺癌的患者采用随机数字表法分为观察组和对照组各50例,两组患者均采用新辅助化疗方案,观察组同时给予排毒汤,观察两组患者在化疗过程中毒副反应的发生情况差异。结果:观察组的血红蛋白降低率、白细胞减少率、粒细胞减少率、血小板减少率及腹泻和呕吐的发生率均显著低于对照组(P<0.05)。两组患者的丙氨酸氨基转移酶升高率、血肌酐升高率及治疗总有效率差异无统计学意义(P>0.05)。化疗后两组患者KPS评分均较化疗前显著提高(P<0.05),且观察组患者KPS评分显著高于对照组(P<0.05)。结论:乳腺癌患者术前新辅助化疗中加用排毒汤能有效降低化疗过程中的毒副反应,同时不会影响新辅助化疗的疗效。
Objective: To observe the preventive effect of detoxification decoction on neoadjuvant chemotherapy in patients with breast cancer before and after chemotherapy. Methods: A total of 100 patients with confirmed breast cancer who were admitted to the Seventh People’s Hospital of Changzhou and Shanghai International Peace Maternity and Child Care Hospital from April 2012 to January 2015 were randomly divided into observation group (50 cases) and control group (50 cases) Two groups of patients with neoadjuvant chemotherapy, the observation group also given detox soup, two groups of patients in the chemotherapy during the occurrence of toxic reactions differences. Results: The decrease of hemoglobin, leukopenia, neutropenia, thrombocytopenia, diarrhea and vomiting in observation group were significantly lower than those in control group (P <0.05). There was no significant difference in the rising rate of alanine aminotransferase, the rising rate of serum creatinine and the total effective rate between the two groups (P> 0.05). The KPS score of both groups after chemotherapy was significantly higher than that before chemotherapy (P <0.05), and the KPS score of the observation group was significantly higher than that of the control group (P <0.05). Conclusion: Preoperative neoadjuvant chemotherapy in breast cancer patients with detoxification soup can effectively reduce the side effects of chemotherapy, while not affecting the efficacy of neoadjuvant chemotherapy.