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目的探讨血清CA199与卵巢成熟性畸胎瘤肿瘤特点之间的关系。方法选取2011年6月~2013年6月在本院妇科手术的卵巢畸胎瘤患者113例进行分析,术前检查包括CA199在内的4种肿瘤标志物。结果 4种血清肿瘤标志物中,CA199的阳性率最高,为43.4%;CA199阳性组肿瘤直径明显大于CA199阴性组(P<0.05);卵巢肿瘤发生蒂扭转与未发生蒂扭转比较,CA199表达有显著性差异,卵巢肿瘤扭转患者CA199阳性表达率明显高于非扭转患者(P<0.01);卵巢肿瘤发生于双侧与单侧比较,CA199的表达差异具有统计学意义,双侧卵巢畸胎瘤患者CA199阳性表达率明显高于单侧肿瘤患者(P<0.01)。结论检测血清CA199水平对卵巢畸胎瘤的诊断和鉴别诊断有重要临床意义,CA199有可能成为监测卵巢畸胎瘤预后与复发的重要指标。
Objective To investigate the relationship between serum CA199 and the characteristics of ovarian mature teratoma. Methods From June 2011 to June 2013, 113 patients with ovarian teratoma who underwent gynecological surgery in our hospital were analyzed. Four kinds of tumor markers including CA199 were examined preoperatively. Results The positive rate of CA199 in the four serum tumor markers was 43.4%. The diameter of tumor in CA199 positive group was significantly higher than that in CA199 negative group (P <0.05) Significant difference, the positive rate of CA199 expression in patients with ovarian tumor was significantly higher than that in non-torsion patients (P <0.01); Ovarian tumor occurred in bilateral and unilateral comparison, the expression of CA199 was statistically significant difference, bilateral ovarian teratoma The positive expression rate of CA199 in patients with unilateral tumor was significantly higher (P <0.01). Conclusion The detection of serum CA199 level has important clinical significance in the diagnosis and differential diagnosis of ovarian teratoma. CA199 may be an important indicator to monitor the prognosis and recurrence of ovarian teratoma.