目的探讨肢端雀斑样黑色素瘤(Acral lentigenous nevus,ALN)的常规HE染色病理诊断经验教训,减少误诊的发生。方法收集近年来经免疫组化标记及上级会诊确诊的肢端雀斑样黑色素瘤6例,对病理误诊情况进行分析。结果在6例肢端雀斑样黑色素瘤患者中,有2例初诊误诊为色素痣,误诊率33.3%。结论肢端雀斑样黑色素瘤极易误诊。 Objective To investigate the experience of routine HE staining pathological diagnosis of acral lentigenous nevus (ALN) to reduce the misdiagnosis. Methods Six cases of acromiocutaneous melanoma diagnosed by immunohistochemistry and upper level consultation in recent years were collected, and the pathological misdiagnosis was analyzed. Results In 6 cases of acromegaly melanoma patients, 2 cases were newly diagnosed as pigmented nevus, the rate of misdiagnosis was 33.3%. Conclusion Acral lentiginous melanoma is easily misdiagnosed.