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目的:建立壮阳制剂中非法掺入的豪莫西地那非的专属性检测方法。方法:壮阳制剂的提取液通过液相色谱-串联四极杆质谱分析,利用相对分子质量、二级质谱碎片信息、液相色谱保留时间3方面信息,对壮阳制剂制剂中非法掺入的西地那非衍生物豪莫西地那非进行定性鉴别。结果:在受试壮阳制剂中,有1种被检测到掺有豪莫西地那非。结论:该方法选择性强,灵敏度高,可作为壮阳制剂中非法掺入豪莫西地那非的有效检测方法。
Objective: To establish a specific detection method for Hawthornide that was illegally incorporated in aphrodisiac preparations. Methods: The extracts of aphrodisiac preparations were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The information on relative molecular mass, MS/MS fragmentation information, and LC retention time were used. The non-derivative Hawthorna was qualitatively identified. Results: One of the tested aphrodisiac formulations was detected with Hawthorna sildenafil. Conclusion: This method is highly selective and sensitive, and it can be used as an effective method for the detection of the illegal incorporation of Haemosildinaf in aphrodisiac preparations.