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本文研究了尼莫地平控释片的释放度试验方法——转篮法，释放介质为含有２２％异丙醇的０．１ｍｏｌ·Ｌ－１盐酸液；磷酸盐缓冲液（ｐＨ５．８）和ｐＨ７．２的溶液。含量测定方法：紫外分光光度法，在三种介质中尼莫地平分别在１～３０μｇ·ｍｌ－１，１０～５０μｇ·ｍｌ－１和１０～５０μｇ·ｍｌ－１的范围内，浓度与吸收度有较好的线性关系。回归方程分别为Ａ＝０．６１５Ｃ＋０．０２３（ｒ＝０．９９９９）；Ａ＝０．０６１４Ｃ＋０．０１２（ｒ＝０．９９９５）；Ａ＝０．０６１２Ｃ＋０．００８８（ｒ＝０．９９９９）。平均回收率分别为９９．６３％，９９．９８％及１００．７７％，ＲＳＤ（％）分别为１．３４％，１．５９％及１．４１％。本方法的体外释放百分率与体内吸收分数有较好的相关性（ｒ＝０．９９１）。
In this paper, the release of nimodipine controlled release tablets test method - basket method, the release medium is containing 0.1mol · L-1 hydrochloric acid solution of 22% isopropanol; phosphate buffer (pH5.8) and pH 7.2 solution. Determination of content: UV spectrophotometry in the three media nimodipine in the range of 1 ~ 30μg · ml-1, 10 ~ 50μg · ml-1 and 10 ~ 50μg · ml-1, the concentration and absorption Have a good linear relationship. The regression equations were A = 0.615C + 0.023 (r = 0.9999); A = 0.0614C + 0.012 (r = 0.9995); A = 0.0612C + 0.0088 (r = 0.9999). The average recoveries were 99.63%, 99.98% and 100.77% respectively, with RSDs of 1.34%, 1.59% and 1.41%, respectively. The method of in vitro release percentage and in vivo absorption score has a good correlation (r = 0.991).