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目的:观察中西医结合治疗慢性乙型肝炎的临床疗效。方法:将286例患者随机分为2组。对照组140例予猪苓多糖合干扰素治疗,治疗组146例在对照组治疗基础上根据中医辨证分型,以自拟保肝清毒汤为基础方随证加减治疗。结果:2组总有效率比较,差异有显著性意义(P<0.05)。治疗组146例,血清谷丙转氨酶(ALT)复常例数为138例,对照组140例,ALT复常例数为89例,ALT复常率分别为94.52%及63.57%。2组比较,差异有显著性意义(P<0.05),治疗组有良好降低ALT近期疗效。治疗组对乙型肝炎病毒(HBV)标志物的近期疗效,在乙肝病毒表面抗原(HBsAg)、乙肝病毒e抗原(HBeAg)和乙肝病毒的脱氧核糖核酸(HBV-DNA)阴转率上均优于对照组,差异有显著性意义(P<0.05)。结论:中西医结合治疗慢性乙型肝炎临床疗效肯定。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of chronic hepatitis B Methods: 286 patients were randomly divided into two groups. Control group of 140 cases of Polyporus umbellatis polysaccharide combined treatment of interferon, 146 cases in the treatment group in the control group based on the treatment according to TCM syndrome type, with self-protection liver qi dang decoction based prescriptions card plus treatment. Results: The total effective rate in the two groups was significantly different (P <0.05). In the treatment group, 146 cases had ALT, 138 cases had ALT, and 140 cases had ALT. The ALT normalization rate was 94.52% and 63.57% respectively. The difference between the two groups was significant (P <0.05), and the treatment group had a good reduction of the short-term effect of ALT. The immediate effect of the treatment group on Hepatitis B virus (HBV) markers was excellent over the negative rates of hepatitis B virus surface antigen (HBsAg), hepatitis B virus e antigen (HBeAg) and hepatitis B virus DNA In the control group, the difference was significant (P <0.05). Conclusion: The clinical efficacy of integrated traditional Chinese and western medicine in the treatment of chronic hepatitis B is positive.