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目的探讨正常血压人群与血压正常高值人群尿酸水平,高尿酸血症患病率及相关心血管事件危险因素的比较。方法采取整群分级抽样方法调查成都市3个社区3524例社区居民血压水平及尿酸等代谢指标,按不同的血压水平分为正常血压组和血压正常高值组,分别比较两组间血尿酸浓度水平、高尿酸血症的患病率及相关心血管事件危险因素差异,并就血压与尿酸及相关代谢指标做相关分析。结果血压正常高值组比正常血压组的血尿酸水平高[(302.91±81.89)μmol/L vs(284.78±78.56)μmol/L,P<0.001],高尿酸血症的患病率在血压正常高值组为8.7%,高于血压正常组4.4%(P=0.002),血压正常高值组的年龄、BMI、血脂、心率、血糖等指标比正常血压组高,差异均有统计学意义。血压与各危险因素的相关性分析显示,收缩压和舒张压与年龄,BMI、尿酸、心率有弱相关,与胆固醇有强相关。结论血压正常高值人群比正常血压人群有着更高的包括高尿酸血症在内的心血管危险因素。
Objective To investigate the prevalence of uric acid, the prevalence of hyperuricemia and the risk factors of cardiovascular events in normotensive and high-normotensive subjects. Methods The cluster sampling method was used to investigate the blood pressure level and uric acid and other metabolic parameters of 3524 community residents in 3 communities in Chengdu. According to the different blood pressure levels, the patients were divided into normotensive group and high normotensive group. The levels of serum uric acid, Level, the prevalence of hyperuricemia and the risk factors related to cardiovascular events, and related analysis of blood pressure and uric acid and related metabolic indicators. Results The prevalence of hyperuricemia was significantly higher in normotensive patients than in normotensive subjects (302.91 ± 81.89 μmol / L vs 284.78 ± 78.56 μmol / L, P <0.001) The high value group was 8.7%, which was higher than that of the normal group (4.4%, P = 0.002). The age, BMI, blood lipid, heart rate, blood glucose and other indexes of high blood pressure normal group were higher than those in normal blood pressure group. Correlation analysis of blood pressure and risk factors showed that systolic blood pressure and diastolic blood pressure were weakly correlated with age, BMI, uric acid and heart rate, and had a strong correlation with cholesterol. Conclusions Cardiovascular risk factors, including hyperuricemia, are higher in normotensive subjects than in normotensive subjects.