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为研究胃大部切除术后残胃粘膜屏障损伤与残胃粘膜癌前病变的关系，在甲基硝基亚硝基胍（ＮｍｅｔｈｙＮ’ｎｉｔｒｏＮｎｉｔｒｏｓｏｇｕａｎｉｄｉｎｅ，ＭＮＮＧ）诱发犬残胃粘膜癌前病变过程中，胃镜下定期行残胃粘膜活检的同时，对跨胃粘膜电位差（ｇａｓｔｒｉｃｔｒａｎｓｍｕｃｏｓａｌｐｏｔｅｎｔｉａｌｄｉｆｅｒｅｎｃｅ，ＧＴＰＤ）及粘膜细胞核ＤＮＡ含量进行了动态测定。结果：随着残胃吻合口粘膜病变加重，ＧＴＰＤ值呈渐进性下降趋势，且ＧＴＰＤ值与相应粘膜细胞核ＤＮＡ含量之间呈显著负相关关系。本实验结果提示：随着残胃粘膜屏障损伤程度的加重，粘膜组织细胞恶变潜能就越大；残胃粘膜屏障损伤在残胃癌前病变发生过程中起着至关重要的作用。
To investigate the relationship between residual gastric mucosal barrier injury and residual gastric mucosal precancerous lesions after subtotal gastrectomy, the dogs were induced by N-methy-N’-nitroNnitrosoguanidine (MNNG). In the course of precancerous lesions of residual gastric mucosa, gastric mucosa biopsy was performed regularly under gastroscope, and the transgastric mucosal potential difference (GTPD) and nuclear DNA content of mucosal cells were dynamically determined. RESULTS: With the aggravation of mucosal lesions in the residual gastric anastomosis, the GTPD values showed a decreasing trend, and there was a significant negative correlation between the GTPD values and the corresponding mucosal nuclear DNA content. The results of this experiment suggest that with the increase of residual gastric mucosal barrier damage, the malignant potential of mucosal tissue cells will be greater; residual gastric mucosal barrier injury plays a crucial role in the process of gastric precancerous lesions.