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目的观察外用重组人干扰素α-2b喷雾剂治疗手足口病的临床疗效。方法对90例手足口病患儿随机分成两组,所有患儿均口服维生素C、利巴韦林颗粒和板蓝根等口服抗病毒药。体温超过38.5℃者给予退热药或物理降温。重组人干扰素α-2b喷雾剂治疗组给予重组人干扰素α-2b喷雾剂外用喷于患儿疱疹处,每天三四次,连用7 d。另一组外用阿昔洛韦软膏。每2 h 1次,每日6次,连用7 d。结果重组人干扰素α-2b喷雾剂治疗组和阿昔洛韦软膏治疗组对比发热和皮疹消退时间短,两组比较,差异有统计学意义(P<0.01)。结论重组人干扰素α-2b喷雾剂外用治疗手足口病取得较为满意效果,疗效确切。
Objective To observe the clinical efficacy of topical interferon alfa-2b spray for the treatment of hand-foot-mouth disease. Methods Ninety children with HFMD were randomly divided into two groups. All children received oral antivirals such as vitamin C, ribavirin granules and Radix Isatidis. Body temperature over 38.5 ℃ to give antipyretics or physical cooling. Recombinant human interferon α-2b spray treatment group given recombinant human interferon α-2b spray applied to children with herpes external application three or four times daily for 7 d. Another group of topical acyclovir ointment. 1 every 2 hours, 6 times a day, once every 7 days. Results The comparison of fever and rash subsided time in recombinant IFN-α-2b spray-treated group and acyclovir ointment group was shorter. There was significant difference between the two groups (P <0.01). Conclusion External application of recombinant human interferon α-2b spray for the treatment of hand, foot and mouth disease is more satisfactory and effective.