A series of segmented poly(L-lactide)-polyurethanes (PLA-Pus) were synthesized by a two-step method, with oligo-poly(L-lactide) (PLA) as the soft segments and the reaction product of2,4-toluene diisocyanate (TDI) and ethylene glycol (EG) as the hard segments. The shape-memory properties and biocompatibility of PLA-Puswere examined. The 50% compressed PLA-Pus could recover almost 100% to their original shape within 10℃ from the lowest recovery temperature (22℃-37℃). In the recovery process the PLA-PU showed a maximum contracting stressin the range of 1.5-4 Mpa. Cell incubation experiments show that PLA-PU has biocompatibility comparable to that of pure PLA. Therefore, this kind of polyurethane can be used for implanted medical devices with shape memory requirements.